Spanning Europe and Asia, exotic Istanbul is one of the world‘s most fascinating cities. Domes and minarets enhance the skyline. In the old Stamboul area, traces remain of every city built since the community was established over 600 years before Christ. Once Rome‘s eastern capital, Istanbul was also the center of the huge Ottoman Empire. Landmarks include Hagia Sophia, once Christendom‘s greatest church; the Blue Mosque with its striking Iznik tiles; Topkapi Palace, containing a sultan‘s ransom of treasures; Chora Church with its Byzantine mosaics; and the Grand Bazaar, the ultimate shopping experience.

Between 1865 and 1866, English explorer Frank Calvert and German archaeologist Heinrich Schliemann began digging trenches through a hillock outside Canakkale and discovered layer upon layer of ancient cities. Ultimately nine cities that had thrived and fallen atop each other were identified with the legendary Greek city of Troy. The site is a UNESCO World Heritage Site.

Deserted for centuries because of constant raids by pirates and the Turks, this tiny arid island was first settled in 1088 when the Emperor of Constantinople made it a gift to the monk Christodoulos Latrnos so that he could establish a monastery in honor of St. John the Divine on the site. Patmos has been a place of scholarship and religious enlightenment ever since. Today this modern pilgrimage site is a quiet respite from the tourist havens many other Greek isles have become.

Symi belongs to the Dodecanese islands and lies across the Asia Minor coast and just a few nautical miles NW of Rhodes. Aristocratic and far off the model of mass tourism, Symi pleasantly surprises its visitors with its plain, aristocratic yet wild beauty. As you glimpse the perfectly formed harbor of Symi, Gialos, you are confronted with a beautiful picture-postcard Venetian village. Wonderfully well-preserved two and three story mansions with their facades painted in bright and vivid colors reflect the island‘s rich past since Symi was once one of the richest islands with a tradition in sponge diving, ship building and wood carving. The history of Symi goes back to ancient times. Aigli, Metapontis and Kariki are some of Symi‘s ancient names where according to mythology the Graces were born. Symi got its current name from the nymph Symi, who according to the myth mated with Poseidon, God of the Seas, and brought to life Hthonios who became the leader of the island‘s first inhabitants.

“Thira, the Wild Island” and “Kalliste, the Fairest One” – all terms of endearment for this seductive, volcanic Greek island in the Sea of Crete. Extraordinary for its black sand beaches and sheer limestone cliffs, Santorini also showcases remnants of the Phoenician, Spartan and Minoan cultures, which fell under the island‘s spell – an unvarying, irresistible lure that continues to this day. Fira, the picturesque, pedestrian-only capital, is reached from the seaport via a short cable car ride that offers thrilling views as you ascend.

Piraeus has been the port for Athens since 482 BC. The busy harbor is filled with ferries and cruise ships making their way to the Greek Islands and other Mediterranean cities. The busy metropolis of Athens and its treasure trove of antiquities lie just a few miles from the port. Even as the reality of the modern city took hold, with its high-rise apartments, crowded sidewalks and bustling traffic, the beauty of the Acropolis, the outstanding museums, charming cafés, sidewalk markets and startling views come together in a cultural mosaic for all to enjoy.

Gythion, the small port town for Sparta, edges its way up the hillside, which surrounds the harbor. According to Homer, Paris and Helen spent their first night together here, on a tiny islet in the bay. To commemorate the occasion, Paris erected a shrine to Aphrodite, goddess of love, only to have it torn down by the vengeful Menelaus after he recaptured Helen. In its place Menelaus erected statues honoring Praxidica (Punishment) and Themis (Justice). Not far away, at the tip of the Peloponnese, lies the Mani, a distinctive area unlike anything else in Greece. This desolate region of underground lakes and rivers and windswept landscapes is strangely beautiful. To the north of Gythion lie Sparta and Mystra, well worth a visit.

Located on the east coast of Kefalonia, Sami is home to beautiful beaches and pleasant cafés and tavernas around the harbor that provide an ideal setting to soak up the traditional Greek atmosphere. Situated on a hill to the south of town are the ruins of ancient Sami, where visitors will find a fascinating site consisting of artifacts spanning several different civilizations over thousands of years.

One of the best preserved medieval towns of the Adriatic, Kotor is protected by UNESCO. Between 1420 and 1797, the area was under the rule of the Republic of Venice and the Venetian influence can be seen in its architecture. The Gulf of Kotor is sometimes called the southernmost fjord in Europe, although it is actually a submerged river canyon. The overhanging limestone cliffs of Orjen and Lovcen complete one of the Mediterranean‘s most beautiful landscapes.

Founded in the 7th century, Dubrovnik rose to greatness as a merchant state, independent republic and cultural crossroads. The traffic-free Old Town has been called a Croatian Athens. This UNESCO designated World Heritage Site is a living museum of the ages with fortifications, chapels, monastic cloisters and Europe‘s second-oldest synagogue crowded into its ancient walls. Relax at a sidewalk café, listen to the chimes of the 14th-century bell tower or join the promenade down the palace-lined avenue known as the Stradun.

This important port on Southern Albania curls around a superb natural harbor, dominated by the hilltop 16th century Lekuresi Castle with distinctive round towers. In the town center are the ruins of a 5th century synagogue, later a Christian basilica, with remnant mosaic floors. Another picturesque ruin is the Forty Saints Monastery from the 6th century, which is thought to have been an important pilgrimage site. But the main attraction in southern Albania is the archaeological site of Butrint, a UNESCO World Heritage Site with extensive ruins of communities dating from prehistory, though the Greek and Roman eras, as well as the Byzantine period, until the medieval period.

This harbor on the eastern shore of Sicily near Messina gives us close access to the fabulous Greco-Roman ruins of Taormina, as well as the active volcano Mt. Etna. The temples, streets and large amphitheater of Taormina make it one of Italy’s premier ancient sites. Its location overlooking the sea and with the backdrop of snow-capped Etna complete the package and make it among the most famous attractions in the Mediterranean region. Giardini Naxos itself boasts a lovely beach at Lido Europa, and intrepid visitors can climb Mt. Etna to see a volcano close up

The Amalfi Coast has been called the greatest meeting of land and sea on earth. Situated in the Campania region between Sorrento and Salerno, Amalfi and Positano are the two main towns on the world-famous Amalfi Drive – renowned as the most scenic and romantic road in Italy. The road is carved into the side of rocky cliffs plunging into the sparkling sea. Erosion has sculpted the rocky slopes into gargoyle shapes and hollowed out fairy grottoes where the air is tinted turquoise by the glowing blue water below. During the Middle Ages, Amalfi was an independent maritime state with a population of 50,000. The ship compass was invented here in 1302. Approximately 10 miles away from Amalfi is the village of Ravello. An enchanting village with wonderful views and quiet lanes, Ravello boasts romantic gardens surrounding medieval ruins, affording magnificent views of the entire Bay of Salerno.

Originally built by Emperor Trajan who had a villa here, Civitavecchia has flourished as a major port for Rome since the 13th century. Today it is an important ferry terminal and for many travelers the gateway to the Eternal City, Rome. The Renaissance fortifications that surround the harbor area were begun by Bramante and completed by Michelangelo in 1535.

The pleasingly green, quiet island of Sardinia offers the visitor scenic beauty and a relaxed lifestyle. Cagliari, the island‘s capital, features handsome Italianate architecture and several churches reflecting a variety of influences. Impressive views are provided by the city‘s hillsides, with one of the best panoramas available from the old walls of Terrazzo Umberto. The island‘s natural charm has attracted pleasure-seekers to the Costa Smeralda since the Aga Khan sought shelter ashore from a storm at sea.

Settled first by the Romans, then ruled by Genoans for nearly half a millennium, Calvi was freed by Corsica‘s native son Napoleon in 1791. In 1982 it was given special status and now enjoys a uniquely autonomous position within the realm of France. Ringed with alternating precipitous cliffs and fine sand beaches, the island resembles a mountain thrust up out of the water, but its ruggedness is tempered by brilliant sunlight and groves of olive and orange trees. Napoleon once said that he could recognize Corsica with his eyes closed – by its perfume alone. While touring Corsica, be advised that the roads about this mountainous island are quite winding with many curves.

Portofino is a charming, popular resort village on the Italian Riviera, a favorite with artists and seasoned travelers. Situated on a beautiful bay, the surrounding mountains covered with dense vegetation of olive and cypress trees, form a unique setting of incomparable beauty. The ship will anchor in the bay and tenders will transport you to this tiny resort village, which is closed to vehicle traffic. Everything is concentrated around a small square offering an opportunity to stroll around on foot, shop, or just relax at one of the many open-air cafes.

On the southern shore of one of the most beautiful bays of the Riviera, the little port of St. Tropez has become one of the best known resorts in Europe, a crossroads where journalists, photographers, writers, artists and celebrities meet. Guy de Maupassant discovered the town, but it was the painters who made it more widely known – Signac, Matisse, Bonnard, Marquet, Camoin – who all stayed for varying amounts of time. The harbor teems with life. Fishing boats, excursion craft and hundreds of yachts share the harbor. On the waterfront are old pink and yellow houses, which have been converted into cafes, cabarets and restaurants, luxury boutiques, galleries and antique shops. A picturesque and cosmopolitan crowd strolls the streets in season.

Founded by Greeks in the pre-Christian era, the Catalan town is set on a lovely curve of beaches on Spain’s Costa Brava. It is crowned by the Castell de la Trinitat, which anchored the wall that encircled the entire town in medieval times. It was the site, until 2011, of Ferran Adria’s Michelin three-star restaurant El Bulli, which will reportedly reopen in 2014 as a culinary creativity center. Shop for a souvenir from the back of a street hawker’s donkey, or wander to nearby Figueres or Cadaques to visit one of Salvador Dali’s museums.

Mahon is the capital of Menorca, second largest of the Balearic Islands. It stands out from the others because of the abundance of prehistoric structures, and because its culture was influenced by British occupation in the 18th century. The people who built the prehistoric constructions are believed to have been responsible for similar works in Sardinia, and for Stonehenge in England. Believed to have been founded by the Carthaginian General Mago, Mahon was held by the Moors from the 8th to the 13th century and in turn occupied by the English, the French and the Spanish. Mahon was finally ceded to Spain by the Treaty of Amiens in 1802.